Increased serum immunoreactive gastrin levels in idiopathic hypertrophic pyloric stenosis.
نویسندگان
چکیده
The serum immunoreactive gastrin (IRG) level in infants with confirmed idiopathic hypertrophic pyloric stenosis (IHPS) has been determined and compared to that found in vomiting infants without IHPS, in normal infants, and in normal adults. The mean serum IRG level of normal infants (103 +/- 9 pg/ml (mean +/- SEM) exceeded that of normal adults (28 +/- 5 pg/ml). The preoperative mean serum IRG level in IHPS infants (256 +/- 26 pg/ml) was significantly higher than that of both normal infants and vomiting infants without IHPS (93 +/- 9 pg/ml). Twenty-five per cent (5/20) of the IHPS infants had serum IRG levels within the upper range of normal infants. Fasting serum IRG levels in IHPS infants were not altered immediately by pyloromyotomy. The results from this study suggest a relationship between gastrin and idiopathic hypertrophic pyloric stenosis.
منابع مشابه
The effect of pyloromyotomy on serum and luminal gastrin in infants with hypertrophic pyloric stenosis.
Previous studies of the pathogenesis of congenital hypertrophic pyloric stenosis (CHPS) have implicated immunoreactive gastrin, although no consistent relationship has been demonstrated. In this study we have examined the effect which pyloromyotomy has on serum and luminal gastrin concentration after a mechanical and protein stimulus. Seventeen infants were examined preoperatively, and 1 week a...
متن کاملPlasma enteroglucagon and neurotensin in infantile pyloric stenosis.
Plasma concentrations of gastrin, somatostatin, neurotensin, and enteroglucagon were measured by radioimmunoassay in normal 30and 45-day-old neonates and age-matched infants with confirmed idiopathic hypertrophic pyloric stenosis. Plasma gastrin and somatostatin concentrations were similar in both groups, whereas neurotensin and enteroglucagon were significantly lower in the pyloric stenosis gr...
متن کاملIs maternal gastrin important in congenital hypertrophic pyloric stenosis?
The birth of a normal infant to a woman with Zollinger-Ellison syndrome is described. The cord blood serum gastrin was very elevated. This suggests that maternal gastrin can cross the placenta, a fact previously in doubt in man. The infant did not develop congenital hypertrophic pyloric stenosis. This is further evidence that raised blood gastrin in utero is not an important causative factor in...
متن کاملWhy Pyloric Stenosis of Infancy Occurs--Simple Echos from the Past
Fasting gastrin levels rise steeply to levels exceeding adult fasting values after birth and do not fall despite the rising gastric acidity in the first few weeks of life. When both gastrin and acid secretion rise together (such as in the Zollinger-Ellison syndrome) the negative feedback between gastrin and antral acidity is not working [2,13,14]. During this time there is no post-prandial gast...
متن کاملFirst Report of A Unique Presentation of Hypertrophic Pyloric Stenosis Following Type I Esophageal Atresia; A Case Report
Combination of congenital esophageal atresia and subsequent hypertrophic pyloric stenosis is a rare condition which occurs in early infancy. The underlying etiology and pathophysiology of this association still remains unclear. In this paper we report a unique case of hypertrophic pyloric stenosis, for the first time, which occurred in an infant who underwent surgery for type I esophag...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Gut
دوره 19 9 شماره
صفحات -
تاریخ انتشار 1978